Role of EPCR in breast cancer progression and metastasis [Tesis]

tesisSe ha introducido en Dadun una nueva Tesis Doctoral:

Título: Role of EPCR in breast cancer progression and metastasis

Autor: Naiara Perurena

Director/es: Fernando Lecanda

Resumen: Endothelial protein C receptor (EPCR) is a transmembrane receptor widely expressed in endothelial cells where it exerts cytoprotective and anticoagulant activities. It is also expressed in lung tumor cells where EPCR promotes tumor cell survival and increases metastatic activity. However, to date the contribution of EPCR to tumorigenesis and metastasis in breast cancer remains ill defined. Global expression analysis in a cohort of 286 breast cancer patients revealed that patients with high EPCR expression levels have significantly shorter relapse-free survival times. In vitro, stimulation with activated protein C (APC) or shRNA-mediated EPCR silencing did not alter growth kinetics of bone metastatic human breast cancer cells in basal or pro-apoptotic conditions. However, subcutaneous and orthotopic inoculation of control and EPCR-silenced (shEPCR) bone metastatic cells showed a marked reduction in tumor growth, while markers of cell growth, apoptosis and angiogenesis were unaffected […].


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