Effects of Maresin 1, an omega-3 fatty acid-derived lipid mediator, on adipose tissue and liver function in obesity [Tesis doctoral]

Se ha introducido en Dadun una nueva Tesis Doctoral:

TítuloEffects of Maresin 1, an omega-3 fatty acid-derived lipid mediator, on adipose tissue and liver function in obesity.

Autor: Laiglesia González, Laura M.

Director: Moreno Aliaga, María Jesús y Lorente Cebrián, Silvia.

Resumen: The present study aimed to determine the potential ability of EPA to remodel metabolism and phenotype of human subcutaneous adipocytes, as well as to characterize the ability of MaR1 to counteract inflammation-induced adipocyte disorders and to elucidate MaR1 actions on brown/beige adipose tissue and liver function in animal models of obesity and in culture cells. This research demonstrated the ability of the n-3 PUFA EPA to increase mitochondrial content, and to activate master regulators of mitochondrial biogenesis and to promote the expression of genes that typify beige adipocytes in cultured fully differentiated human subcutaneous adipocytes from overweight subjects…

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